Skeleton Factory was originally a printing and publishing house. The company was established around the turn of the 19th century in a nearby town. Around 1935, the company moved to this location. Initially the family's country house was located here. In 1930 the printing house's owner purchased a pavilion that had served at the Liège World's Fair and had it rebuilt behind his country house. This pavilion housed the printing company in 1935. In the years that followed, the company developed into the complex we see today.

The printing company originally primarily printed postcards. This involved printing photographs taken by the owner (himself a photographer) of places like the Belgian coast. A few years before his death, the focus shifted from postcards, whose successful period had passed, to mainly labels. His son, who was already working as a printer in the company, took over the enterprise after his father’s death. He changed the printing company's operations and switched to industrial printing.

Between 1948 and 1976, the company was taken over several times by American multinationals. Because no investments were made, revenue declined rapidly. In 2004, the company closed down, and the 46 remaining employees lost their jobs.

The vacant factory hall is currently best known for the beautiful examples of graffiti art by street artists Klaas Van der Linden (the skeletons) and ROA (the animals).